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KMID : 0360419750110010047
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Korean Journal of Pharmacology
1975 Volume.11 No. 1 p.47 ~ p.53
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Studies on the Effects CC1₄ on Exocrine Puncrease
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Abstract
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The metabolism of many drugs and also of steroid hormones is mediated by enzymes lcoated in the microsomal fraction in smooth surfaced endoplasmic reticulum of mammalian liver. The duration and iotensity of action of many drugs are largely determined by the speed at which they are metabolized in the body.
Repeated administration of phenobarbital results in the induction of enzymes that metabolize a number of drugs. Lee et al. reported that daily administration of phenobarbital in rats significantly increased the activities of amylase in the pancreatobiliary juice, but the concentration of cholate in the bile was significantly lower in the treated group than that in the control group.
After animals were treated with CCl₄, histological changes were shown in the endoplasmic reticulum, decreased microsomal enzyme activity and decreased hepatic protein synthesis were apparent.
The purpose of the present report was to study the interaction between a "microsomal-stimulating" agent such as phenobarbital and a "microsomal- depressing" agent such as CCl₄ on hepatic and pancreatic functions in rats.
The results obtained are summarized as follows:
1. The mortality rate of CCl₄ treated group was 34% and was decreased this figure to 15% with Phenobarbital pretreatment.
2. In animals treated with phenobarbital the volume of biliary-pancreatic secretion was markedly elevated but the volume was decreased significantly in animals treated with CCl₄.
3. Total bilirubin output was elevated markedly in the CCl₄ treated group of rats pretreated with phenobarbital. The bilirubin concentration was increased in CCl₄ treated group and decreased in the group treated phenobarbital alone.
4. The concentration and total output of cholate in the bile were significantly lower in the all experimental group than control group.
5. In the animals treated with phenobarbital alone and phenobarbital plus CCl₄, the activity of lipase in pancreatobiliary juice was elevated, while in the animals treated with CCl₄ alone no change was observed.
6. The activity of amylase in the pancreatobiliary juice was decreased in the CCl₄ treated group, but elevated markedly in phenobarbital group and also elevated in phenobarbital-CCl₄ group.
By the above results, it is concluded, when the liver was damaged by CCl₄, the exocrine function of pancreas and liver was decreased simultaneously. However, in the animals pretreated with phenobarbital, the toxicity of CCl₄ on the liver and pancreas was reduced.
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